RPC8, NT (POLR3H, KIAA1665, RPC8, DNA-directed RNA polymerase III subunit RPC8, DNA-directed RNA polymerase III subunit H, RNA polymerase III subunit

Affinity Purified Purified by Protein A affinity chromatography.

Rpc31p

RPC8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between amino acid 10-40 from the N-terminal region of human RPC8.

RPC8 is DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. It is plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. It is acting as nuclear and cytosolic DNA sensor involved in innate immune response. It can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-Kappa-B through the RIG-I pathway.

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Polyclonal

ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS)

Human, Mouse

Anti -RPC8, NT (POLR3H, KIAA1665, RPC8, DNA-directed RNA polymerase III subunit RPC8, DNA-directed RNA polymerase III subunit H, RNA polymerase III subunit 22.9kD subunit)

855571

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