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TGIF1, ID (L223) (TGIF1, TGIF, Homeobox protein TGIF1, 5'-TG-3'-interacting factor 1)
品牌： MyBioSource
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对比
咨询反应种属：
Human, Mouse
实验应用：
ELISA (EL/EIA), Western Blot (WB)
产品介绍
产品介绍
产品信息
纯化方式
Purified
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
免疫原
TGIF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-245 amino acids from the Central region of human TGIF1.
商品描述
The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described.
形式
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
产品类型
Polyclonal
应用
实验应用
ELISA (EL/EIA), Western Blot (WB)
反应种属
Human, Mouse
背景
别名
Anti -TGIF1, ID (L223) (TGIF1, TGIF, Homeobox protein TGIF1, 5'-TG-3'-interacting factor 1)
制备和贮存
保存方式
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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