LIMK1, phosphorylated (Thr508) (LIMK1, LIMK, LIM domain kinase 1)

Affinity Purified Purified by Protein A affinity chromatography.

LIM domain kinase 1 isoform 2

Phospho-LIMK1 (Thr508) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected surrounding Thr508 of human LIMK1.

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. [provided by RefSeq].

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Polyclonal

ELISA (EL/EIA), Gel Shift Assay (GS/EMSA)

Human

Anti -LIMK1, phosphorylated (Thr508) (LIMK1, LIMK, LIM domain kinase 1)

3984

P53667 [Other Products]