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产品介绍
产品介绍
产品信息
荧光素标记
HRP
抗原名称
Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed : 19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed : 19092802, PubMed : 19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed : 19092802, PubMed : 19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed : 11980720, PubMed : 28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed : 28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed : 28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed : 16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed : 15543136).
宿主
Rabbit
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
简单描述
HRP兔单克隆抗体[EP1704Y] to WSTF
商品描述
Rabbit Recombinant Monoclonal WSTF antibody - conjugated to HRP.
同种型
IgG
克隆号
EP1704Y
克隆类别
单克隆
纯度
Protein A purified
形式
Liquid
研究领域
表观遗传学
应用
实验应用
Antibody Labelling, Target Binding Affinity
背景
别名
WBSC10, WBSCR10, WBSCR9, WSTF, BAZ1B, Tyrosine-protein kinase BAZ1B, Bromodomain adjacent to zinc finger domain protein 1B, Williams syndrome transcription factor, Williams-Beuren syndrome chromosomal region 10 protein, Williams-Beuren syndrome chromosomal region 9 protein, hWALp2
研究领域
Epigenetics and Nuclear Signaling Chromatin Remodeling ISWI/NURF/CHRAC Epigenetics and Nuclear Signaling Transcription Other factors
制备和贮存
存储溶液
pH: 7.40Preservative: 0.1% Proclin 300 SolutionConstituents: 30% Glycerol (glycerin, glycerine), 1% BSA, 68% PBS
保存方式
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. Store In the Dark.
数据库链接
UniProt ID
Q9UIG0
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