PE Anti-CMTM6 antibody [EPR23015-45]

Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.

Rabbit

Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

PE兔单克隆抗体[EPR23015-45] to CMTM6

IgG

EPR23015-45

单克隆

Protein A purified

0.5 mg/mL 本产品的浓度可能与批次相关

Liquid

免疫学和肿瘤学

Target Binding Affinity, Antibody Labelling

CKLFSF6, CMTM6, CKLF-like MARVEL transmembrane domain-containing protein 6, Chemokine-like factor superfamily member 6

pH: 7.40Preservative: 0.02% Sodium azideConstituents: 98% PBS, 1% BSA

Q9NX76