HRP Anti-Thrombomodulin antibody [SP309] (C-terminal)

HRP

Purified from TCS by protein A/G.

Endothelial cell receptor that plays a critical role in regulating several physiological processes including hemostasis, coagulation, fibrinolysis, inflammation, and angiogenesis (PubMed : 10761923). Acts as a cofactor for thrombin activation of protein C/PROC on the surface of vascular endothelial cells leading to initiation of the activated protein C anticoagulant pathway (PubMed : 29323190, PubMed : 33836597, PubMed : 9395524). Also accelerates the activation of the plasma carboxypeptidase B2/CPB2, which catalyzes removal of C-terminal basic amino acids from its substrates including kinins or anaphylatoxins leading to fibrinolysis inhibition (PubMed : 26663133). Plays critical protective roles in changing the cleavage specificity of protease-activated receptor 1/PAR1, inhibiting endothelial cell permeability and inflammation (By similarity). Suppresses inflammation distinctly from its anticoagulant cofactor activity by sequestering HMGB1 thereby preventing it from engaging cellular receptors such as RAGE and contributing to the inflammatory response (PubMed : 15841214).

Rabbit

Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

HRP兔单克隆抗体[SP309] to Thrombomodulin - C-terminal

IgG

SP309

单克隆

Protein A/G purified

Liquid

其他

Target Binding Affinity, Antibody Labelling

CD141, THRM, THBD, Thrombomodulin, TM, Fetomodulin

pH: 7.40Preservative: 0.1% Proclin 300 SolutionConstituents: 30% Glycerol (glycerin, glycerine), 1% BSA, 68% PBS

P07204