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HRP Anti-PHD1/prolyl hydroxylase antibody [EPR2745]
品牌： Abcam
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咨询纯度：
Protein A purified
来源宿主：
Rabbit
产品介绍
产品介绍
产品信息
荧光素标记
HRP
抗原名称
Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed : 11595184, PubMed : 12039559, PubMed : 15925519, PubMed : 16509823, PubMed : 17114296, PubMed : 23932902). Target proteins are preferentially recognized via a LXXLAP motif (PubMed : 11595184, PubMed : 12039559, PubMed : 15925519). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed : 11595184, PubMed : 12039559, PubMed : 12181324, PubMed : 15925519, PubMed : 19339211). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed : 11595184, PubMed : 12039559, PubMed : 12181324, PubMed : 15925519). Also hydroxylates HIF2A (PubMed : 11595184, PubMed : 12039559, PubMed : 15925519). Has a preference for the CODD site for both HIF1A and HIF2A (PubMed : 11595184, PubMed : 12039559, PubMed : 15925519). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed : 11595184, PubMed : 12039559, PubMed : 15925519). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed : 11595184, PubMed : 12039559, PubMed : 15925519). EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (PubMed : 11595184, PubMed : 12039559, PubMed : 15925519). Also regulates susceptibility to normoxic oxidative neuronal death (PubMed : 11595184, PubMed : 12039559, PubMed : 15925519). Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (PubMed : 23932902). Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (PubMed : 17114296). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity).
宿主
Rabbit
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
简单描述
HRP兔单克隆抗体[EPR2745] to PHD1/prolyl hydroxylase
商品描述
Rabbit Recombinant Monoclonal PHD1/prolyl hydroxylase antibody - conjugated to HRP.
同种型
IgG
克隆号
EPR2745
克隆类别
单克隆
纯度
Protein A purified
形式
Liquid
研究领域
其他
应用
实验应用
Antibody Labelling, Target Binding Affinity
背景
别名
EIT6, EGLN2, Prolyl hydroxylase EGLN2, Egl nine homolog 2, Estrogen-induced tag 6, HPH-3, Hypoxia-inducible factor prolyl hydroxylase 1, Prolyl hydroxylase domain-containing protein 1, EIT-6, HIF-PH1, HIF-prolyl hydroxylase 1, HPH-1, PHD1
研究领域
Cardiovascular Hypoxia Prolyl Hydroxylase Epigenetics and Nuclear Signaling Cardiovascular/Immune Hypoxia Prolyl hydroxylase Cancer Invasion/microenvironment Hypoxia Hydroxylases Cancer Cancer Metabolism Response to hypoxia Metabolism Pathways and Processes Metabolism processes Hypoxia
制备和贮存
存储溶液
pH: 7.40Preservative: 0.1% Proclin 300 SolutionConstituents: 30% Glycerol (glycerin, glycerine), 1% BSA, 68% PBS
保存方式
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. Store In the Dark.
数据库链接
UniProt ID
Q96KS0
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