MSLN/Mesothelin (298-600) His Tag Protein, Mouse

品牌： UA BIOSCIENCE

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参数

分子量：

纯度：

产品介绍

产品信息

荧光素标记

Unconjugated

氨基酸序列

Asp298-Ser600, with C-8*His

分子量

39-50kDa (Reducing)

纯度

＞95% by SDS-PAGE

内毒素水平

<0.1EU/μg

性状

Lyophilized powder

表达系统

HEK293

缓冲体系

PBS, pH7.4

标签

His Tag

种属

Mouse

电泳JSON

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背景

别名

MPF,SMRP

背景

Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte potentiating factor, which belongs to the mesothelin family. Mesothelin/MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin/MSLN can interact with MUC16. The membrane-anchored form of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.

Mesothelin (MSLN) is a lineage restricted cell surface protein expressed in about 30% of human cancers and high MSLN expression is associated with poor survival in several different cancers. The restricted expression of MSLN in normal tissue and its frequent expression in cancers make MSLN an excellent target for antibody-based therapies.

制备和贮存

溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

保存方式

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.

数据库链接

Accession

Q61468

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货号：

UA010175-100μg

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