ADRB2 Recombinant Rabbit mAb (S-2418-144)

The ADRB2 (β2-adrenergic receptor) is a 413-amino-acid G-protein-coupled receptor embedded in the plasma membrane of airway, vascular, and adipose tissues, where it binds epinephrine and norepinephrine to trigger intracellular signaling cascades via Gs-mediated adenylyl cyclase activation, elevating cAMP and PKA to relax bronchial and vascular smooth muscle, modulate lipolysis, and influence cardiac output; encoded on chromosome 5q31–32, ADRB2 is highly polymorphic—most notably the Arg16Gly and Gln27Glu variants that alter down-regulation and desensitization—making it a pharmacogenomic target for β2-agonists in asthma and COPD therapy, and its structure has been captured in both active and inactive conformations by X-ray crystallography, revealing the molecular basis of agonist efficacy, inverse agonism, and biased signaling exploited in modern drug design.