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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
纯化方式
Protein A
抗原名称
PMS2
宿主
Rabbit
免疫原
Synthetic Peptide
克隆号
SDT-111-307
浓度
0.5 mg/ml
性状
Liquid
缓冲体系
PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300
产品类型
Recombinant mAb
应用
实验应用
IHC-P、ICC、ICFCM
反应种属
Hu
稀释度
IHC
1:2000ICC
1:500ICFCM
1:500
背景
别名
Mismatch repair endonuclease PMS2, DNA mismatch repair protein PMS2, PMS1 protein homolog 2
背景
This gene is one of the PMS2 gene family members which are found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. The protein forms a heterodimer with MLH1 and this complex interacts with MSH2 bound to mismatched bases. Defects in this gene are associated with hereditary nonpolyposis colorectal cancer and Turcot syndrome. So joint detection of MLH1, MSH2, PMS2, and MSH6 can be used for screening of hereditary non polypic colon cancer (Lynch syndrome).
细胞定位
Nucleus
制备和贮存
保存方式
12 months from date of receipt / reconstitution, -20 °C as supplied
数据库链接
Accession
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