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ADAM8 Recombinant Rabbit mAb (S-2546-23)

ADAM8 Recombinant Rabbit mAb (S-2546-23)

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反应种属:
Hu
来源宿主:
Rabbit
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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
纯化方式
Protein G
抗原名称
ADAM8
宿主
Rabbit
免疫原
Recombinant Protein
同种型
IgG
克隆号
S-2546-23
浓度
0.5 mg/ml
性状
Liquid
缓冲体系

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

产品类型
Recombinant mAb
应用
实验应用
WB
反应种属
Hu
稀释度
  • ELISA

  • Sandwich ELISA

  • CLIA

  • Lateral Flow

  • Dot Blot

  • WB

    1:1000
  • IP

  • IHC-P

  • ICC

  • IF

  • ICFCM

  • FCM

  • mIHC

  • ChIP

背景
别名
Disintegrin and metalloproteinase domain-containing protein 8; Cell surface antigen MS2; CD156a; MS2
背景

ADAM8 (a disintegrin and metalloproteinase domain 8), also designated CD156a, is a type-I transmembrane metalloproteinase encoded at 10q26.3 that belongs to the ADAM family of cell-surface sheddases; its modular architecture comprises a pro-domain, catalytic metalloprotease, disintegrin-like, cysteine-rich, EGF-like, transmembrane, and cytoplasmic tail domains, endowing it with the dual capacity to cleave extracellular-matrix proteins such as fibronectin and collagen while simultaneously regulating cell–cell and cell–matrix interactions through its disintegrin motif. Physiologically, ADAM8 is expressed at highest levels in immune and neuronal tissues, where it modulates leukocyte transmigration, cytokine and chemokine shedding (e.g., TNF-α, CX3CL1), and neuronal adhesion during development and repair; pathologically, its marked up-regulation in cancers promotes epithelial-to-mesenchymal transition, angiogenesis, and metastasis by attenuating intercellular adhesion and degrading matrix barriers, and in allergic asthma it orchestrates airway remodeling and hyper-responsiveness, rendering ADAM8 a prognostic biomarker and an attractive therapeutic target for anti-metastatic and anti-inflammatory interventions .

细胞定位
Membrane
制备和贮存
保存方式

12 months from date of receipt / reconstitution, -20 °C as supplied

数据库链接
Accession
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货号:
S0B6301-25μl
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