TSG101 Recombinant Rabbit mAb (S-1868-76)

TSG101 (Tumor Susceptibility Gene 101) is an essential 380-amino-acid human protein that contains an N-terminal UEV (ubiquitin E2 variant) domain and a proline-rich C-terminal region, functioning as the core subunit of the ESCRT-I complex that drives membrane scission events during multivesicular body formation, viral budding and cytokinesis by recognizing mono-ubiquitinated cargo via its UEV domain and coupling it to downstream ESCRT machinery, while its misregulation or truncation, originally identified in a screen for tumor suppressor genes, is linked to neoplastic transformation, defective cell cycle checkpoints and chromosomal instability.