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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
纯化方式
Protein A
抗原名称
NTRK1/TrkA
宿主
Rabbit
免疫原
Synthetic Peptide
同种型
IgG
克隆号
S-2524-16
浓度
2 mg/ml
性状
Liquid
缓冲体系
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
产品类型
Recombinant mAb
应用
实验应用
WB
反应种属
Hu
稀释度
ELISA
Sandwich ELISA
CLIA
Lateral Flow
Dot Blot
WB
1:500-1:1000IP
IHC-P
ICC
IF
ICFCM
FCM
mIHC
ChIP
背景
别名
High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A (Trk-A); MTC; TRK; TRKA
背景
NTRK1/TrkA, encoded on chromosome 1q23.1, is a 140 kDa high-affinity receptor tyrosine kinase for nerve growth factor (NGF) that, upon ligand-induced dimerization and autophosphorylation at Tyr490, Tyr751 and Tyr785, activates the PI3K/Akt, Ras/MAPK and PLCγ pathways to orchestrate neuronal survival, differentiation, nociception and evasion of apoptosis, while its fusion proteins or mutations can drive oncogenesis and are targeted by TRK inhibitors.
细胞定位
Cell membrane
制备和贮存
保存方式
12 months from date of receipt / reconstitution, -20 °C as supplied
数据库链接
Accession
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