LPA Rabbit Polyclonal Antibody

LPA protein refers to apolipoprotein(a), the distinctive glycoprotein covalently linked via a single disulfide bond to apolipoprotein B-100 on a low-density lipoprotein (LDL)-like particle to form lipoprotein(a) [Lp(a)], a liver-synthesized macromolecule whose circulating concentration—ranging from undetectable to >100 mg/dL and varying more than 1,000-fold among individuals—is almost entirely dictated by the LPA gene’s size polymorphism of kringle IV repeats, rendering levels largely fixed from early childhood and minimally responsive to diet, lifestyle, or standard LDL-lowering therapies. Beyond its structural role, apo(a)’s striking sequence homology to plasminogen imparts anti-fibrinolytic and pro-thrombotic properties, while its capacity to bind oxidized phospholipids and promote macrophage lipid uptake confers potent atherogenicity, making elevated Lp(a) an independent, causal risk factor for atherosclerotic cardiovascular disease, calcific aortic stenosis, and thrombo-embolic events, although its precise physiological function remains elusive.