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产品信息
荧光素标记
Unconjugated
纯化方式
Protein A
抗原名称
PTP1B
宿主
Rabbit
同种型
IgG
克隆号
S-R304
浓度
0.5 mg/ml
性状
Liquid
缓冲体系
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
产品类型
Recombinant mAb
应用
实验应用
WB、IHC-P、IP
反应种属
Hu、Ms
稀释度
WB
1:1000IP
1:50IHC-P
1:2000
背景
别名
Tyrosine-protein phosphatase non-receptor type 1, Protein-tyrosine phosphatase 1B (PTP-1B), PTPN1
背景
PTP1B was first isolated from a human placental protein extract, but it is expressed in many tissues. It is localized to the cytoplasmic face of the endoplasmic reticulum. PTP1B can dephosphorylate the phosphotyrosine residues of the activated insulin receptor kinase. PTP1B is a negative regulator of the insulin signaling pathway and is considered a promising potential therapeutic target, in particular for treatment of type 2 diabetes. It has also been implicated in the development of breast cancer and has been explored as a potential therapeutic target in that avenue as well.
细胞定位
Membrane、Endoplasmic reticulum
制备和贮存
保存方式
12 months from date of receipt / reconstitution, -20°C as supplied
数据库链接
Accession
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