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Anti-HER2 Monoclonal Antibody(Pertuzumab)
品牌： STARTER
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对比
咨询来源宿主：
Human
实验应用：
Blocking of HER2 signaling Functional assays
产品介绍
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产品信息
荧光素标记
Unconjugated
纯化方式
Protein A
宿主
Human
同种型
IgG1,k
克隆号
S-SC018
内毒素水平
<1EU/mg
浓度
2 mg/ml
性状
Liquid
缓冲体系
PBS pH7.4, containing no preservative
产品类型
Recombinant mAb
应用
实验应用
Blocking of HER2 signaling Functional assays
稀释度
ELISA
1.221-5000 ng/ml
背景
别名
Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein (MLN 19), Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, CD340, ERBB2, MLN19, NEU, NGL
背景
Pertuzumab is a monoclonal antibody used in combination with trastuzumab and docetaxel for the treatment of metastatic HER2-positive breast cancer; it also used in the same combination as a neoadjuvant in early HER2-positive breast cancer. It is the first-in-class of a kind of drug called a "HER dimerization inhibitor" — it inhibits the dimerization of HER2 with other HER receptors, which prevents them from signalling in ways that promote cell growth and proliferation.
制备和贮存
保存方式
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
数据库链接
Accession
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