RB1CC1 Recombinant Rabbit mAb (S-2367-251)

RB1CC1 (also known as FIP200) is a multifunctional 183-kDa scaffolding protein that nucleates the ULK1-ATG13-RB1CC1-ATG101 complex to initiate autophagosome formation in response to nutrient or mTOR signals, acts in the nucleus as a GC-rich DNA-binding transcription factor that up-regulates RB1, p16 and p21 to enforce cell-cycle checkpoints, and simultaneously controls migration, differentiation and survival by inhibiting the focal-adhesion kinases PTK2/FAK1 and PTK2B/PYK2 and by modulating TSC1, p53 and TGF-β pathways, thereby operating as a central tumor-suppressor whose loss or mis-localation is linked to aggressive breast, prostate and pancreatic cancers as well as to fibrotic and neuro-developmental disorders.