Glycogen Synthase Recombinant Rabbit mAb (S-2698-24)

Glycogen Synthase (GS) is the key rate-limiting enzyme in the glycogen biosynthesis pathway, primarily responsible for catalyzing the elongation of the glycogen chain. It uses uridine diphosphate glucose (UDP-Glucose) as the activated glucose donor, adding glucose molecules via α-1,4-glycosidic bonds to a pre-existing glycogen primer chain, thereby linearly extending the glucose polymer. The activity of this enzyme is precisely regulated by both allosteric control and covalent modification (reversible phosphorylation): the insulin signaling pathway activates its activity through dephosphorylation, promoting glycogen storage; whereas stress hormones like glucagon and adrenaline cause its inactivation through phosphorylation, thereby inhibiting glycogen synthesis and mobilizing energy release. Thus, Glycogen Synthase is a central molecule in maintaining the body's glucose homeostasis, and its aberrant activity is closely associated with metabolic diseases such as Type II diabetes and insulin resistance.