MFG1-E8 Recombinant Rabbit mAb (S-2530-74)

Milk fat globule-EGF factor 8 (MFG-E8), also called lactadherin, is a secreted 66–75 kDa glycoprotein composed of an N-terminal EGF-like domain containing an RGD integrin-binding motif and two C-terminal discoidin/F5-8 domains that bind phosphatidylserine, enabling it to act as a bridging molecule between apoptotic cells and phagocytes expressing αvβ3/αvβ5 integrins, thereby orchestrating efferocytosis, dampening inflammation, and exerting pleiotropic effects on vascular remodeling, skeletal-muscle lipid metabolism, myogenic differentiation, osteoclastogenesis, and tumor progression while also giving rise to the amyloidogenic peptide medin found in aged arterial walls.