SLC10A1/NTCP1 Recombinant Rabbit mAb (S-2844-23)

The SLC10A1 gene encodes the sodium/bile acid cotransporter NTCP1, a 349-amino-acid, 7-transmembrane-domain glycoprotein that is almost exclusively expressed on the basolateral membrane of hepatocytes, where it uses the inward Na⁺ gradient to mediate high-affinity uptake of conjugated bile acids and, notably, also serves as the principal entry receptor for hepatitis B and D viruses, while additional substrates including steroid sulfates, thyroid hormones, and certain drugs link NTCP1 to systemic bile acid homeostasis, lipid metabolism, and pharmacokinetics, and inherited or acquired dysregulation of the transporter produces cholestatic disorders that are increasingly targeted by small-molecule or siRNA therapeutics.