Lipocalin-2/NGAL Recombinant Rabbit mAb (S-2280-129)

Lipocalin-2/NGAL is a 25-kDa secreted glycoprotein of the lipocalin superfamily that forms an 8-stranded β-barrel calyx able to bind and transport ferric siderophore complexes, thereby acting as a bacteriostatic innate immune factor that starves bacteria of iron while simultaneously delivering iron to mammalian cells via the megalin/24p3R receptor, and is rapidly induced by inflammatory, hypoxic or nephrotoxic stress in neutrophils, macrophages and epithelia, circulates as monomer, homodimer or MMP-9–linked heterodimer, functions as a sensitive biomarker of acute and chronic kidney injury, modulates cell survival, differentiation, epithelial-to-mesenchymal transition and oncogenesis, and is transcriptionally up-regulated through NF-κB, ERK and JAK-STAT pathways in metabolic disorders such as obesity and insulin resistance.