IGF2BP1 Recombinant Rabbit mAb (S-2947-19)

IGF2BP1 (Insulin-like growth factor-2 mRNA-binding protein 1) is a 63-kDa oncofetal RNA-binding protein that contains four KH and two RRM domains and preferentially binds thousands of coding and non-coding transcripts—most prominently IGF2, MYC, KRAS, MDR1, and β-TRCP1 mRNAs—via conserved CAUH (H = A/C/U) motifs in their 3′-UTRs, thereby protecting them from endonucleolytic cleavage and miRNA-mediated silencing, stabilizing the transcripts, enhancing their translation, and consequently driving cell growth, self-renewal, migration, and chemoresistance in embryonic, stem, and cancer cells; the protein dynamically shuttles between the nucleus and cytoplasm in a methylation- and phosphorylation-regulated manner, localizes to stress granules and P-bodies, and its elevated expression in hepatocellular, colorectal, ovarian, pancreatic, and triple-negative breast carcinomas correlates with advanced stage, metastasis, and poor prognosis, making IGF2BP1 a promising prognostic biomarker and therapeutic target.