Stat5b Recombinant Rabbit mAb (S-2951-34)

Stat5b (signal transducer and activator of transcription 5b) is a 787-amino-acid transcription factor that, upon phosphorylation by JAK kinases in response to cytokines such as IL-2, GH, prolactin or IFN-α, dimerizes and translocates to the nucleus where it binds the consensus GAS motif TTCNNNGAA to regulate genes controlling cell survival, proliferation, differentiation and metabolic reprogramming; it is indispensable for normal immune homeostasis, mammary gland development and liver GH signaling, and its persistent activation is a driver of multiple hematologic and solid cancers, making Stat5b a validated therapeutic target.