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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated

纯化方式
Protein A

抗原名称
Phospho-ULK1 (Ser757)

宿主
Rabbit

同种型
IgG

克隆号
S-3495

浓度
0.5 mg/ml

性状
Liquid

缓冲体系
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

产品类型
Recombinant mAb

应用
实验应用
WB、ICC

反应种属
Hu

稀释度
ELISA
Sandwich ELISA
CLIA
Lateral Flow
Dot Blot
WB
1:1000IP
IHC-P
ICC
1:100IF
ICFCM
FCM
mIHC
ChIP
背景
别名
Serine/threonine-protein kinase ULK1; Autophagy-related protein 1 homolog (ATG1; hATG1); Unc-51-like kinase 1; KIAA0722; ULK1

背景
Phospho-ULK1 (Ser757) is the phosphorylated form of the serine/threonine kinase ULK1 at serine 757, a modification catalyzed by mTORC1 under nutrient-rich conditions that disrupts ULK1’s interaction with AMPK and keeps autophagy suppressed; upon starvation or rapamycin-triggered mTORC1 inhibition, Ser757 dephosphorylation enables AMPK binding and subsequent phosphorylation of activation-loop sites, licensing ULK1 kinase activity and initiating autophagosome formation.

细胞定位
Cytoplasm

制备和贮存
保存方式
12 months from date of receipt / reconstitution, -20 °C as supplied
数据库链接
Accession
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