NRF1 Recombinant Rabbit mAb (S-2409-103)

NRF1 (Nuclear Respiratory Factor 1) is a ubiquitously expressed transcription factor that functions as a master regulator of nuclear-encoded mitochondrial genes by binding to GC-rich promoter elements, thereby orchestrating mitochondrial biogenesis, oxidative phosphorylation, and cellular redox homeostasis; it also controls the expression of key components of the proteasome and lysosome systems, maintains mitochondrial DNA transcription and replication, and its activity is modulated by post-translational modifications and subcellular localization, making it essential for energy metabolism, cell survival, and adaptation to metabolic stress.