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CL-82198
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产品介绍
产品介绍
产品信息
抗原名称
0
简单描述
CL-82198 是 MMP-13选择性抑制剂。它能够与 MMP-13 的整个 S1' 口袋结合，这是其对 MMP-13 选择性和对其他 MMP 缺乏抑制活性的基础。它可用于研究骨关节炎。
商品描述
CL-82198, a selective MMP-13 inhibitor, serves as a pharmacological intervention to halt the progression of osteoarthritis (OA). Its mechanism of action involves binding to the S1’ pocket of MMP-13, ensuring its selectivity and preventing inhibition of other MMPs.
分子量
302.37
纯度
95.91%
性状
Solid
颜色
Yellow
In vitro(体外研究)
CL-82198 decreases CTGF and TGF-β1 protein levels in hepatic stellate cells[3]. CL-82198 (10 μM; 24 hours) obviously reduces LS174 cell migration[1].
In vivo(体内研究)
CL82198 (1-10 mg/kg; i.p.; every other day for 12 weeks) treatment avoids and decelerates MLI-induced osteoarthritis progression.
背景
别名
0
分子式
C17H22N2O3
CAS号
307002-71-7
密度
1.159 g/cm3 (Predicted)
制备和贮存
溶解方法
DMSO: 100 mg/mL (330.72 mM), Sonication is recommended.
存储溶液
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
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