ABT-510 acetate

ABT-510 acetate 是一种内源性抗血管生成的 TSP 肽抑制剂，是一种凝血酶原类似物，具有抗炎抗癌和抗血管生成活性，能诱导肿瘤细胞凋亡并抑制上皮性卵巢癌正位、同种异体模型中的卵巢肿瘤生长。ABT-510 acetate 可减少小鼠炎症性肠病模型的血管生成和炎症反应，可用于癌症 (尤其是上皮性卵巢癌) 以及炎症性肠病 (IBD) 的研究。

ABT-510 acetate is an endogenous anti-angiogenic TSP peptide inhibitor, a thrombospondin analog, with anti-inflammatory, anti-cancer and anti-angiogenic activity that induces apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer.ABT-510 acetate reduces angiogenesis and inflammatory responses in a mouse model of inflammatory bowel disease. ABT-510 acetate reduces angiogenesis and inflammation in mouse models of inflammatory bowel disease (IBD) and can be used in cancer research, particularly in epithelial ovarian cancer, as well as in inflammatory bowel disease (IBD).

1054.28

95.07%

ABT-510 acetate （1, 5, 10, 20, 50 nM; 24小时）在ID 8细胞中诱导凋亡，并增加了人类上皮癌细胞系SKOV3、OVCAR3和CAOV3的凋亡发生率。[1] ABT-510 acetate （0-10 μM; 7天）抑制NO刺激的血管细胞生长及入侵到细胞外基质中，阻断肿瘤驱动的血管细胞生长、NO驱动的cGMP通量以及CD36介导的脂肪酸摄取。[3]

ABT-510 acetate （100 mg/kg；腹腔内；每日一次，连续90天）在体内诱导细胞凋亡并显著减小小鼠上皮性卵巢肿瘤大小、腹水体积以及次级病损扩散。[1] ABT-510 acetate （60 mg/kg；皮下渗透泵；每日一次，连续7天）减少了炎症性肠病小鼠模型中的血管新生和炎症。[2]

ABT 510 acetate

C48H87N13O13

442526-87-6

no data available

H2O: 90.0 mg/mL (85.4 mM), Sonication is recommended.

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.