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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
纯化方式
Protein G
抗原名称
B7-H4
宿主
Mouse
同种型
IgG1,k
克隆号
S-3024
浓度
2 mg/ml
性状
Liquid
缓冲体系
PBS pH7.4
产品类型
Mouse mAb
应用
实验应用
FCM
反应种属
Hu
稀释度
ELISA
Sandwich ELISA
CLIA
Lateral Flow
Dot Blot
WB
IP
IHC-P
ICC
IF
ICFCM
FCM
1:2000mIHC
ChIP
背景
别名
V-set domain-containing T-cell activation inhibitor 1; B7 homolog 4 (B7-H4); B7h.5; Immune costimulatory protein B7-H4; Protein B7S1; T-cell costimulatory molecule B7x; B7H4; VTCN1
背景
B7-H4, also known as VTCN1 or B7x, is a ~50 kDa type-I trans-membrane glycoprotein of the B7 immunoglobulin superfamily that consists of an extracellular IgV-IgC domain pair, a single trans-membrane segment and a short cytoplasmic tail; it is expressed inducibly on antigen-presenting cells and constitutively on many epithelial cancers, where it acts as an immune-checkpoint ligand by binding an as-yet-unidentified receptor on activated CD4⁺ and CD8⁺ T cells, thereby arresting the cell cycle in G0/G1, suppressing IL-2 production and proliferation, and enabling tumours to evade immunity, making it an emerging target for cancer immunotherapy.
细胞定位
Cell membrane
制备和贮存
保存方式
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
数据库链接
Accession
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