Glutamate Receptor 1 Recombinant Rabbit mAb (S-1892-144)

Glutamate Receptor 1 (GluR1, also called GRIA1 or AMPA-R subunit 1) is a 906-aa transmembrane protein that assembles with other AMPA-type ionotropic glutamate-receptor subunits into Ca2+-permeable, fast-desensitizing ligand-gated channels that mediate the majority of rapid excitatory neurotransmission in the mammalian CNS; its cytoplasmic C-tail contains a PDZ-binding motif that docks PSD-95 family scaffolds and regulates activity-dependent phosphorylation (Ser831/Ser845) and membrane trafficking, thereby controlling synaptic strength, long-term potentiation, learning, memory, and pathological excitotoxicity in stroke, epilepsy, and neurodegeneration.