Beta I tubulin Recombinant Rabbit mAb (S-3108-63)

Beta I tubulin, the most neuron-enriched β-tubulin isoform encoded by TUBB1, is a ~50 kDa globular protein that heterodimerizes with α-tubulin to assemble neuron-specific microtubule arrays, stabilizing axonal and dendritic cytoskeletons through GTP-dependent head-to-tail polymerization and interaction with microtubule-associated proteins; its unique C-terminal tail undergoes reversible glutamylation and detyrosination to regulate motor-protein trafficking, synaptic plasticity and axonal transport, while missense mutations (e.g., V180A, R215W) disrupt microtubule dynamics and cause a spectrum of neurodevelopmental disorders termed “tubulinopathies” characterized by simplified gyral pattern, microcephaly and intellectual disability, making Beta I tubulin a critical determinant of neuronal morphology and human brain development.