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GENZ-882706
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产品介绍
产品介绍
产品信息
抗原名称
0
简单描述
GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor.
商品描述
GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor.
分子量
455.51
纯度
0
性状
0
颜色
0
In vitro(体外研究)
Genz-882706 induces an increased level of proliferative activity on unstimulated cells 48 hours post treatmen.
In vivo(体内研究)
Daily treatment with Genz-882706 significantly reduces experimental autoimmune encephalomyelitis. Treatment with Genz-882706 in experimental autoimmune encephalomyelitis (EAE) mice results in significant decreases in MCP-1, IL-6, IL-Ιβ and IP-10 levels in spinal cord homogenates when compared to Vehicle treated animals. Treatment with Genz-882706 shows a significant increase in TNF-a levels in the spinal cord when compared to the vehicle treated group. Genz-882706 at both the 30 mg/kg and the 100 mg/kg dose significantly reduces the number of microglia and monocytes/macrophages in the brain and spinal cord compared to the vehicle and LPS controls. Treatment with Genz-882706 modestly reduces CD80 expression on monocytes/macrophages in the brain.
背景
别名
RA03546849
分子式
C26H25N5O3
CAS号
2070864-35-4
密度
1.29 g/cm3 (Predicted)
制备和贮存
溶解方法
0
存储溶液
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
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