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BIP-135
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产品介绍
产品介绍
产品信息
抗原名称
GSK-3α:16 nM, GSK-3β:21 nM
简单描述
BIP-135 是一个高效、选择性的，ATP 竞争性的 GSK-3 抑制剂，对 GSK-3α 和 GSK-3β 作用的 IC50 值分别为 16 nM 和 21 nM。BIP 135 具有神经保护作用。
商品描述
BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor. With IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect[1].
分子量
421.24
纯度
99.93%
性状
0
颜色
0
In vitro(体外研究)
BIP-135 (20 μM; 48 hours) is a superior neuroprotective agent in the model of oxidative stress[1]. BIP-135 (20-30 μM; 72 hours) increases the survival motor neuron (SMN) protein levels at a dose of 25 μM in human SMA fibroblasts. And the typical bell-shaped dose-response curve is observed due to some toxicity at higher concentrations[1].
In vivo(体内研究)
BIP-135 (75 mg/kg; i.p.; daily; from postnatal day 0 to 21) prolongs the median survival time of Δ7 SMA KO mouse model of spinal muscular atrophy. And it does not appear to be toxic and was well-tolerated by the animals (no decrease in body weight)[1].
背景
别名
0
分子式
C21H13BrN2O3
CAS号
941575-71-9
密度
1.64±0.1 g/cm3 (20 °C, 760 mmHg)
制备和贮存
溶解方法
DMSO: 56.7 mg/mL (134.6 mM), Sonication and heating to 60℃ are recommended.
存储溶液
keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
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