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PF-06273340
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产品介绍
产品介绍
产品信息
简单描述
PF-06273340 是一种口服具有活力的、具有选择性的外周限制性Trk 泛抑制剂。
商品描述
PF-06273340 is an effective, Selective, and Peripherally Restricted Pan-Trk inhibitor (IC50: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM). PF-06273340 has low metabolic turnover in HLM and hHep is a good substrate for efflux transporters P-gp (ER = 35.7) and BCRP (ER = 4.0) and has moderate passive permeability (RRCK Papp = 5.4 × 10 6 cm s 1).
分子量
479.92
纯度
98.00%
背景
别名
PF-6273340, PF6273340, PF 6273340, PF 06273340
分子式
C23H22ClN7O3
CAS号
1402438-74-7
密度
1.47 g/cm3 (Predicted)
制备和贮存
溶解方法
H2O: Insoluble DMSO: 90 mg/mL (187.53 mM), Sonication is recommended. Ethanol: 1 mg/mL (2.08 mM), Sonication is recommended.
存储溶液
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
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