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PF-5006739
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产品介绍
产品介绍
产品信息
抗原名称
CK1:17.0 nM, CK1δ:3.9 nM
简单描述
PF-5006739 is an effective and selective inhibitor of CK1δ/ε (IC50s: 3.9 nM and 17.0 nM, respectively). PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selectivity. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity. PF-5006739 decreases opioid drug-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner.
商品描述
PF-5006739 is an effective and selective inhibitor of CK1δ/ε (IC50s: 3.9 nM and 17.0 nM, respectively). PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selectivity. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity. PF-5006739 decreases opioid drug-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner.
分子量
419.45
纯度
0
性状
0
颜色
0
In vitro(体外研究)
0
In vivo(体内研究)
0
背景
别名
0
分子式
C22H22FN7O
CAS号
1293395-67-1
密度
no data available
制备和贮存
溶解方法
0
存储溶液
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
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