MCB-613

MCB-613 是类固醇受体共激活因子 (SRC) 小分子“刺激物” (SMS)，超刺激 SRCs 的转录活性。它促进 SRC 与其他共激活因子发生相互作用，并显著诱导 ER 应激与活性氧的产生相结合。它是一种 SMS，能够过度刺激 SRC 致癌程序，靶向癌基因用作抗癌药物。

MCB-613 is an effective steroid receptor coactivator (SRC) stimulator.

304.39

99.33%

Solid

White

MCB-613 selectively and reversibly binds to the RID of SRC-3, and selectively kills cancer cells including MCF-7 (breast), PC-3 (prostate), H1299 (lung), and HepG2 (liver) cells, without toxicity to mouse primary hepatocytes and mouse embryonic fibroblasts (MEFs). MCB-613 also increases SRCs' interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS). [1]

In an MCF-7 breast cancer mouse xenograft model, MCB-613 (20 mg/kg, i.p.) significantly and dramatically inhibits the growth of the tumor while causing no obvious animal toxicity and body weight less. [1]

MCB 613

C20H20N2O

1162656-22-5

1.159 g/cm3 (Predicted)

H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: 56 mg/mL (183.97 mM), Sonication is recommended. DMSO: 56 mg/mL (183.97 mM), Sonication is recommended.

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.