HSF1 Recombinant Rabbit mAb (S-3139-44)

Heat shock factor 1 (HSF1) is an evolutionarily conserved transcription factor that acts as the master regulator of the inducible heat-shock response by binding to heat-shock elements (HSEs) in the promoters of cytoprotective chaperone genes such as HSP70 and HSP90, thereby driving rapid expression of molecular chaperones that prevent stress-induced protein misfolding and aggregation; beyond this canonical cytoprotective role, HSF1 also modulates diverse cellular processes including development, metabolism, apoptosis and aging, is frequently hijacked by cancers to sustain oncogenic protein homeostasis and promote malignant proliferation, and is therefore emerging as a key therapeutic target in both protein-misfolding disorders and cancer.