NAT10 Recombinant Rabbit mAb (S-2547-125)

NAT10 (N-acetyltransferase 10) is a 116 kDa, 1,025-amino-acid enzyme that constitutes the sole known “writer” of N4-acetylcytidine (ac4C) on RNA, an evolutionarily conserved modification it installs co-transcriptionally in tRNA, 18S rRNA, mRNA and snoRNA by coupling ATP/GTP hydrolysis to acetyl-CoA-dependent catalysis through its tri-domain architecture—an N-terminal GNAT acetyltransferase core, a central tRNA-binding THUMP domain, and a C-terminal RNA-helicase module—while also acting as a lysine acetyltransferase for histones and non-histone proteins such as α-tubulin and Eg5, thereby integrating epigenetic regulation, ribosome biogenesis, translation fidelity, cell-cycle progression and apoptosis; in human cancers NAT10 frequently undergoes nucleo-cytoplasmic mis-localization via mutations in its bipartite nuclear-localization signals (residues 68-75 and 989-1018), driving cytoskeletal remodeling, metastasis and chemo-resistance, and its expression is further controlled by PIWI-interacting RNAs and stress pathways, making it a central metabolic and oncogenic signaling node.