ATP7B Recombinant Rabbit mAb (S-2827-58)

ATP7B is a P-type ATPase copper-transporting beta polypeptide that acts as the liver-specific efflux pump, using ATP hydrolysis to move cytosolic Cu⁺ across membranes into the trans-Golgi network for incorporation into ceruloplasmin or, when copper is elevated, to vesicles that fuse with the canalicular membrane to excrete excess copper into bile, thereby maintaining systemic copper homeostasis; mutations in ATP7B disable this export, causing toxic hepatic and brain copper accumulation that defines the autosomal-recessive disorder Wilson disease.