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MAPKAPK-2 Recombinant Rabbit mAb (S-2641-58)
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MAPKAPK-2 Recombinant Rabbit mAb (S-2641-58)

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反应种属:
Hu、Ms、Rt、Mk
来源宿主:
Rabbit
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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
纯化方式
Protein A
抗原名称
MAPKAPK-2
宿主
Rabbit
免疫原
Synthetic Peptide
同种型
IgG
克隆号
S-2641-58
浓度
0.5 mg/ml
性状
Liquid
缓冲体系

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

产品类型
Recombinant mAb
应用
实验应用
WB
反应种属
Hu、Ms、Rt、Mk
预测反应种属
Hm, Rb
稀释度
  • ELISA

  • Sandwich ELISA

  • CLIA

  • Lateral Flow

  • Dot Blot

  • WB

    1:1000-1:2000
  • IP

  • IHC-P

  • ICC

  • IF

  • ICFCM

  • FCM

  • mIHC

  • ChIP

背景
别名
MAP kinase-activated protein kinase 2; MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAP-K2; MK-2; MK2; MAPKAPK2
背景

MAPKAPK-2 (commonly referred to as MK2) is a serine/threonine protein kinase encoded by the MAPKAPK2 gene and serves as the most pivotal direct substrate of p38 MAPK, acting as a signaling hub in inflammation, tumorigenesis, the DNA damage response, and cellular senescence. In its resting state, MK2 remains inactive due to an autoinhibitory conformation formed between its C-terminal regulatory domain and its kinase domain. Upon exposure to cellular stress, inflammatory cytokines, or pathogen stimulation, p38α phosphorylates MK2 at Thr334, triggering a conformational switch that simultaneously exposes a nuclear export signal (NES) —promoting p38-bound MK2 translocation to the cytoplasm—and masks its C-terminal nuclear localization signal (NLS) , thereby directing p38 signaling precisely toward cytoplasmic targets. Activated MK2 executes pleiotropic functions via phosphorylation of a diverse substrate repertoire: in the cytoplasm, it phosphorylates HSP27 to remodel the actin cytoskeleton and facilitate cell migration; in RNA metabolism, it phosphorylates ARE-binding proteins such as Tristetraprolin (TTP) and hnRNP A0, causing their 14-3-3-mediated sequestration and inactivation, thereby stabilizing the mRNAs of pro-inflammatory cytokines including TNF-α, IL-6, and IL-1β—a core mechanism driving chronic inflammation. Within the nucleus, MK2 phosphorylates transcription factors such as CREB and SRF, and contributes to maintaining the G2/M checkpoint by regulating the stability of GADD45A mRNA following DNA damage. Recent studies have expanded the functional landscape of MK2 far beyond the classical inflammatory axis: within the tumor microenvironment, MK2 promotes cell survival, drives epithelial-mesenchymal transition (EMT), and confers chemoresistance (e.g., desensitizing pancreatic cancer to gemcitabine and tongue squamous cell carcinoma to paclitaxel), positioning it as a promising target for overcoming drug resistance. In senescent cells, the mTOR pathway selectively upregulates MK2 translation via 4EBP1; the accumulated MK2 then phosphorylates ZFP36L1, relieving its degradation of SASP component mRNAs and thereby establishing the senescence-associated secretory phenotype (SASP).

细胞定位
Cytoplasm、Nucleus
制备和贮存
保存方式

12 months from date of receipt / reconstitution, -20 °C as supplied

数据库链接
Accession
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货号:
S0B6741-25μl
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