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CCL21 Recombinant Rabbit mAb (S-3198-156)
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CCL21 Recombinant Rabbit mAb (S-3198-156)

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反应种属:
Ms、Rt
来源宿主:
Rabbit
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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
纯化方式
Protein A
抗原名称
CCL21
宿主
Rabbit
免疫原
Recombinant Protein
同种型
IgG
克隆号
S-3198-156
浓度
0.5 mg/ml
性状
Liquid
缓冲体系

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

产品类型
Recombinant mAb
应用
实验应用
WB、IHC-P
反应种属
Ms、Rt
稀释度
  • ELISA

  • Sandwich ELISA

  • CLIA

  • Lateral Flow

  • Dot Blot

  • WB

    1:1000
  • IP

  • IHC-P

    1:500
  • ICC

  • IF

  • ICFCM

  • FCM

  • mIHC

  • ChIP

背景
别名
C-C motif chemokine 21a; 6Ckine; Beta-chemokine exodus-2; Small-inducible cytokine A21a; Thymus-derived chemotactic agent 4 (TCA4); Ccl21a; Scya21; Scya21a
背景

CCL21 (also known as secondary lymphoid tissue chemokine SLC or Exodus-2) is a CC-type chemokine of approximately 12.2 kDa consisting of 111 amino acids, encoded by the CCL21 gene on chromosome 9p13.3. Its structure is highly distinctive: although it contains a conserved chemokine domain (including the N-loop and third β-strand) and exists as a monomer, it differs from most family members by possessing six cysteines (two more than typical CC chemokines) and an exceptionally long, unstructured carboxyl-terminal tail. This C-terminal region, while not involved in canonical chemokine folding, facilitates CCL21 anchoring to the surface of lymphatic endothelial cells via glycosaminoglycan binding. Under physiological conditions, CCL21 is predominantly expressed by endothelial cells of secondary lymphoid organs such as lymph nodes, spleen, and appendix. It binds via tyrosine 12 (Y12) in its N-loop and the third β-strand to the N-terminus of the G protein-coupled receptor CCR7 with a dissociation constant of approximately 150 μM, activating downstream signaling pathways including JAK/STAT. This interaction exerts potent chemotactic effects on CCR7⁺ cells (e.g., naïve T cells and dendritic cells), driving their homing to lymphoid organs and establishing immune microenvironments. In the oncological context, however, the CCL21/CCR7 axis exhibits a pronounced double-edged sword effect: various solid tumors—including melanoma and breast cancer—hijack this homing mechanism to actively metastasize to the lymphatic system. Moreover, aberrant CCL21 expression within the primary tumor microenvironment recruits immunosuppressive cells and constructs pro-tumor lymphoid niches, directly correlating with poor prognosis in patients.

细胞定位
Secreted
制备和贮存
保存方式

12 months from date of receipt / reconstitution, -20 °C as supplied

数据库链接
Accession
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货号:
S0B6740-25μl
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