Neutrophil Elastase (ELA2) Recombinant Rabbit mAb (S-3766-3)

Neutrophil elastase is a serine protease stored in azurophilic granules of neutrophils, released during inflammation to degrade extracellular matrix components including elastin, collagen, and fibronectin. While essential for immune defense against pathogens, dysregulated activity contributes to tissue destruction in chronic inflammatory diseases such as chronic obstructive pulmonary disease (COPD), cystic fibrosis, and acute respiratory distress syndrome (ARDS). It also modulates inflammatory signaling by processing cytokines and chemokines, making it a therapeutic target for inflammatory and autoimmune conditions.