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MAGE-A4 Recombinant Rabbit mAb (S-3868-66)
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MAGE-A4 Recombinant Rabbit mAb (S-3868-66)

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反应种属:
Hu
来源宿主:
Rabbit
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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
纯化方式
Protein A
抗原名称
MAGE-A4
宿主
Rabbit
免疫原
Synthetic Peptide
同种型
IgG
克隆号
S-3868-66
浓度
0.5 mg/ml
性状
Liquid
缓冲体系

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

产品类型
Recombinant mAb
应用
实验应用
WB、IHC-P
反应种属
Hu
稀释度
  • ELISA

  • Sandwich ELISA

  • CLIA

  • Lateral Flow

  • Dot Blot

  • WB

    1:1000
  • IP

  • IHC-P

    1:2000
  • ICC

  • IF

  • ICFCM

  • FCM

  • mIHC

  • ChIP

背景
别名
Melanoma-associated antigen 4; Cancer/testis antigen 1.4 (CT1.4); MAGE-4 antigen; MAGE-41 antigen; MAGE-X2 antigen; MAGE4; MAGEA4
背景

MAGE-A4 (Melanoma-Associated Antigen A4) is a cancer-testis antigen belonging to the MAGE-A family, which is normally expressed exclusively in immune-privileged sites such as the testis and placenta but is aberrantly reactivated in a wide variety of malignant tumors including synovial sarcoma, lung squamous cell carcinoma, head and neck cancers, and melanoma. As an intracellular protein processed and presented on the cell surface by Major Histocompatibility Complex (MHC) class I molecules, MAGE-A4 serves as a highly specific tumor-associated antigen that is largely absent from normal somatic tissues, making it an attractive target for immunotherapeutic strategies such as T-cell receptor (TCR)-engineered T cells, peptide vaccines, and antibody-drug conjugates. Its expression is often correlated with tumor progression and poor prognosis in certain cancers, and because of its restricted normal tissue distribution, therapies targeting MAGE-A4 aim to maximize tumor killing while minimizing off-target toxicity, although careful monitoring is required due to potential low-level expression in some normal tissues or the risk of cross-reactivity with other MAGE family members.

细胞定位
Nucleus
制备和贮存
保存方式

12 months from date of receipt / reconstitution, -20 °C as supplied

数据库链接
Accession
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货号:
S0B6809-25μl
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