SMC1 Recombinant Rabbit mAb (S-4147-54)

SMC1 (Structural Maintenance of Chromosomes 1) is a highly conserved ATPase subunit of the cohesin complex, which plays a pivotal role in maintaining chromosomal architecture and ensuring genomic stability in eukaryotic cells. As a core component of the ring-shaped cohesin structure, SMC1 dimerizes with SMC3 to form the structural backbone that topologically entraps sister chromatids, thereby facilitating sister chromatid cohesion from S-phase until anaphase onset to guarantee accurate chromosome segregation during cell division. Beyond its canonical function in mitosis and meiosis, SMC1 is critically involved in DNA double-strand break repair via homologous recombination, regulation of gene expression through chromatin looping, and the establishment of proper three-dimensional genome organization. Mutations or dysregulation of SMC1 are associated with severe developmental disorders known as cohesinopathies, such as Cornelia de Lange syndrome, and are also implicated in various cancers, highlighting its essential nature in both cellular physiology and human disease pathology.