Alexa Fluor® 488 Mouse Anti-Human CD270 Antibody (S-2915)

CD270, also known as TNFRSF14 or Herpesvirus Entry Mediator (HVEM), is a member of the TNF-receptor superfamily. It is a type I transmembrane protein that plays a crucial role in mediating the entry of herpes simplex virus into cells through its interaction with the viral envelope glycoprotein D (gD). The cytoplasmic region of CD270 binds to several TRAF family members, which are involved in signal transduction pathways that activate the immune response . CD270 is widely expressed in various tissues, including blood vessels, brain, heart, and immune cells such as T cells and B cells . Its interactions with ligands like LIGHT (TNFSF14) and LTα are also important for immune regulation .