PerCP-Cy5.5 Mouse Anti-Human CD158 Antibody (S-2918)

CD158, also known as killer-cell immunoglobulin-like receptor (KIR), is a polymorphic type I transmembrane glycoprotein expressed chiefly on natural killer (NK) cells and subsets of T cells that recognizes specific HLA class I allotypes (HLA-A, -B or -C) and transmits either inhibitory or activating signals—depending on whether its cytoplasmic tail contains ITIMs or associates with the ITAM-bearing adaptor DAP12—to regulate cytotoxic activity, thereby serving as a critical immune checkpoint whose blockade is being explored clinically to unleash NK-cell mediated anti-tumor responses.