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RMC-5127
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产品介绍
产品介绍
产品信息
抗原名称
KRas G12V
商品描述
RMC-5127 is an orally bioavailable, mutant-selective tri-complex inhibitor of the GTP-bound (ON) form of RASG12V. It non-covalently binds cyclophilin A (CypA) to form a binary complex that creates a high-affinity tri-complex with RASG12V(ON), sterically blocking effector binding and potently suppressing RAS signaling. It exhibits CNS penetration and induces robust anti-tumor activity in KRASG12V-mutant NSCLC, PDAC, and CRC xenograft models.
分子量
1062.33
纯度
≥98%
可溶性
DMSO : 100 mg/mL (94.13 mM)
外观
White to off-white solid
背景
分子式
C57H75N9O9S
制备和贮存
保存方式
Store at -20℃ for three years（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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