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mIHC
c-Fos is a nuclear phosphoprotein that plays a pivotal role in cell signaling, proliferation, and differentiation. It forms a heterodimer with c-Jun, which then forms the activator protein-1 (AP-1) complex. This complex binds to specific DNA sequences in the promoter and enhancer regions of target genes, transforming extracellular signals into changes in gene expression. c-Fos is crucial in regulating cell development and maintaining skeletal formation. The expression of c-Fos is associated with various biological processes, including cell proliferation, differentiation, and programmed cell death. Additionally, c-Fos is involved in learning and memory processes, with changes in its expression observed in brain regions associated with recognition, working, and fear-related memory. c-Fos is also used as a marker for neural activity, with its expression linked to changes in neuronal function and plasticity. The expression of c-Fos is also related to the occurrence and development of cancer. The c-Fos protein can serve as a marker for tumorigenesis, and its dysregulation is associated with cancer progression. The absence of c-Fos leads to significant neurological abnormalities in mice embryos during development, indicating that c-Fos plays an important role in neurogenesis and brain development.
12 months from date of receipt / reconstitution, -20 °C as supplied
参考图片
WB result of c-Fos Recombinant Rabbit mAb
Primary antibody: c-Fos Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: untreated HeLa whole cell lysate 20 µg
Lane 2: HeLa starve overnight, then treated with 200 nM PMA for 4 hours whole cell lysate 20 µg
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 41 kDa
Observed MW: 38~60 kDa
IHC shows positive staining in paraffin-embedded human colon. Anti- c-Fos antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human stomach. Anti- c-Fos antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human lung adenocarcinoma. Anti- c-Fos antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded mouse stomach. Anti- c-Fos antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded rat colon. Anti- c-Fos antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
Expression of c-Fos in tumor tissue