APC Rat Anti-Mouse I-A/I-E Antibody (M5/114.15.2)

Mouse I-A/I-E refers to the murine major histocompatibility complex class II (MHC class II) molecules, which play a central role in the immune system by presenting antigens to T cells. The I-A and I-E molecules are expressed on the surface of antigen-presenting cells (APCs), such as B cells, macrophages, and dendritic cells, and are responsible for displaying peptides derived from extracellular proteins to CD4+ T cells. This interaction is crucial for initiating the adaptive immune response. Antibodies against mouse I-A/I-E can be used in various scientific applications, including flow cytometry, immunohistochemistry, and immunoprecipitation. These antibodies can target MHC class II molecules in different species, including mice, and are essential tools for research in immunology and cell biology.