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PD-L2 (D6L5A) CO-0114-594 SignalStar Oligo-Antibody Pair

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PD-L2 (D6L5A) CO-0114-594 SignalStar Oligo-Antibody Pair

品牌： CST

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产品介绍

产品信息

来源纯化

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala85 of mouse PD-L2 protein.

简单描述

SignalStar multiplex immunohistochemistry (IHC) is an advanced technology for labeling multiple proteins simultaneously in tissue samples using specific primary antibodies and fluorescent detection reagents. This technology offers accuracy and reliability in visualizing and analyzing protein expression while maintaining spatial context and tissue architecture.

SignalStar Oligo-Antibody Pairs are compatible with the SignalStar Multiplex IHC Buffer Kits for use in fluorescent multiplex imaging experiments. This product includes the oligo-conjugated antibodies and complementary oligos required for labeling your target protein on up to 10 slides. SignalStar Multiplex IHC Buffer Kits are required to amplify and image the target signal. Multiple oligo-antibody pairs can be conveniently combined into a multiplex panel using the SignalStar Multiplex IHC Panel Builder. SignalStar Multiplex IHC Kits & Reagents are not compatible with all of Cell Signaling Technology® products and protocols that are recommended for use in immunohistochemical assays.

商品描述

Product Usage Information

Application	Dilution
SignalStar™ Leica Bond	1:50 - 1:200
SignalStar™ Manual	1:50 - 1:200

应用

目标/特异性

Specificity/Sensitivity

PD-L2 (D6L5A) Rabbit mAb (SignalStar™ Conjugate 0114) recognizes endogenous levels of total PD-L2 protein. Staining of unknown specificity in mouse ovary has been observed.

Species Reactivity:

Mouse

背景

Programmed cell death 1 ligand 2 (PD-L2, B7-DC, CD273) is a member of the B7 family of cell surface ligands that regulate T cell activation and immune responses (1,2). PD-L2 binds the PD-1 transmembrane receptor and inhibits T cell activation. PD-L2 was discovered following a search for novel B7 protein homologs and was later shown to be expressed by activated dendritic cells, macrophages, and T cells (1,3). Similar in structure to related B7 family members, PD-L2 protein contains extracellular IgV and IgC2 domains, a transmembrane domain, and a short, cytoplasmic region. Research studies demonstrate that PD-L2 is expressed in several tumor types, including lung cancer, renal cell carcinoma, melanoma, Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma (4-7). 1.Latchman, Y. et al. (2001) Nat Immunol 2, 261-8. 2.Tseng, S.Y. et al. (2001) J Exp Med 193, 839-46. 3.Messal, N. et al. (2011) Mol Immunol 48, 2214-9. 4.Kim, M.Y. et al. (2015) Lung Cancer 88, 24-33. 5.Taube, J.M. et al. (2014) Clin Cancer Res 20, 5064-74. 6.Green, M.R. et al. (2010) Blood 116, 3268-77. 7.Ansell, S.M. et al. (2015) N Engl J Med 372, 311-9.

制备和贮存

保存方式

SignalStar conjugates are supplied in PBS (pH 7.2), less than 0.1% sodium azide, 2 mM EDTA, 0.05% Triton X-100, 2 mg/mL BSA, and 50% glycerol. Complementary oligos are supplied in nuclease-free water. Store at -20°C. Do not aliquot the antibody. All components in this kit are stable for at least 12 months when stored at the recommended temperature.

数据库链接

Entrez-Gene ID

58205

UniProt ID

Q9WUL5

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货号：

51148S

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