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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
来源纯化
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly842 of human SENP6 protein.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:200 |
同种型
Rabbit IgG
分子量
150
应用
目标/特异性
Specificity/Sensitivity
SENP6 (F2K4K) Rabbit mAb recognizes endogenous levels of total SENP6 protein. This antibody may detect a band of unknown origin at 80 kDa in some cell lines.
Species Reactivity:
Human
敏感性
Endogenous
背景
背景
SUMOylation is a post-translational modification (PTM) that involves the covalent attachment of small ubiquitin-related modifier (SUMO) proteins to substrate proteins. SUMOylation is a reversible process that can be erased by SUMO-specific proteases (SENPs) (1). SENP6 is a critical factor for cell cycle progression and survival (2-4). SENP6 has been shown to deconjugate SUMO2/3 polymers on a group of DNA damage response proteins and is required for maintaining genomic stability (5).
1.Tokarz, P. and Woźniak, K. (2021) Cancers (Basel) 13, 2059. doi: 10.3390/cancers13092059.
2.Dou, H. et al. (2010) Mol Cell 39, 333-45.
3.Liebelt, F. et al. (2019) Nat Commun 10, 3987.
4.Hattersley, N. et al. (2011) Mol Biol Cell 22, 78-90.
5.Claessens, L.A. et al. (2023) Nat Commun 14, 5893.
翻译后修饰
unmodified
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
26054
UniProt ID
Q9GZR1
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